Regular consumption of coffee is associated with a reduced risk of primary sclerosing cholangitis (PSC), autoimmune liver disease, according to a study conducted at the Mayo Clinic in the U.S., advances the portal Isaúde. CSF is an inflammatory disease of the bile ducts, which results in inflammation and subsequent fibrosis, which can lead to liver cirrhosis, liver failure and cancer of the bile ducts. "Although rare, PSC has extremely negative effects.